College football betting picks: NCAAF week 10 rundown and odds

The first edition of the College Football Playoff Rankings was released this week, beginning to paint the picture of what is at stake down the stretch.

As things currently sit, Ohio State leaped up to 1^st in the rankings. The reigning National Champion Georgia Bulldogs sit right behind them in second place while Michigan ranks third and Florida State rounds out the top four.

While these four teams have had the look of the best in college football thus far, the season is far from over and there is a case to be made that as many as the top 12 teams could find a way into the playoffs depending on the results of these final weeks of the season. As things currently stand, Washington sits in 5^th, Oregon 6^th, Texas 7^th, Alabama 8^th, Oklahoma 9^th, Ole Miss 10^th, Penn State 11^th, and Missouri in 12^th in the playoff rankings.

The pack will likely sort itself out as there are several notable matchups between the top teams to close out the season and little to no margin for error. It also should be noted that these are different than the AP poll which will still be used as the primary rankings in this article. Georgia remains the top team in the AP poll with a few other subtle differences throughout.

With each game meaning more at this point in the season, there are plenty of games to keep an eye on and plenty of value in the college football betting markets.

Here is a look at some of the most prominent matchups of the Week 10 slate and where there is the most intriguing value on the betting markets. 

Win odds overview for this week’s matchups

• Clemson (+130 ML) vs Notre Dame (-3) | DraftKings
• Kansas State (+165 ML) vs Texas (-4) | BetMGM
• Texas A&M (+130 ML) vs Ole Miss (-3) | BetRivers
• Arizona State (+330 ML) vs Utah (-11) | Betway
• Missouri (+500 ML) vs Georgia (-15) | Unibet
• Maryland (+275 ML) vs Penn State (-8.5) | DraftKings
• Oklahoma State (+180 ML) vs Oklahoma (-6) | BetMGM
• USC (+125 ML) vs Washington (-3) | BetRivers
• LSU (+130 ML) vs Alabama (-3)| Betway
• Colorado (+400 ML) vs Oregon State (-13.5) | Unibet

NCAAF weekly predictions

There are four matchups between teams in the Top 25 this week although the Bedlam matchup between Oklahoma and Oklahoma State might as well count as one.

Georgia will be looking to make a statement following the recent Ohio State push and can do just this against Missouri who will be their toughest opponent so far this year. They will also be tested to close the year as they will face off against Ole Miss and Tennessee before finishing the regular season against Georgia Tech.

Washington will also be looking to climb into the top four as Michael Penix Jr gets set to duel with projected top pick Caleb Williams and USC. With USC having already suffered losses to Notre Dame and Utah, a cap has been put on their ceiling for the season so Washington may be catching them at the right time.

In addition, LSU will get set to duel with Alabama, Kansas State is matching up with Texas, and Oklahoma will face off against Oklahoma State in the final Bedlam matchup as members of the Big 12.

As things currently stand, Michigan and Georgia are co-favorites to win the National Championship at +240 odds on DraftKings Sportsbook. Despite leading the pack in the first College Football Playoff Rankings, Ohio State is 4^th in National Championship odds at +700 with Florida State in front of them at +600.

The November 25^th matchup between Ohio State and Michigan is sure to be a statement matchup that both sides will have circled on their calendars. This game is sure to have the full attention of the college football world and will surely shift the championship odds one way or another.

Michigan QB J.J. McCarthy (+300) has once again fallen behind Washington QB Michael Penix Jr. (+280) in the Heisman race. Despite it looking like Penix Jr. was running away with the race a few weeks ago, things have opened up once again. LSU QB Jayden Daniels is not far behind at +400 while Oregon QB Bo Nix holds +600 odds and Florida State QB Jordan Travis sits at +800.

There also is some growing momentum for Ohio State WR Marvin Harrison Jr. looking to be the first non-QB to win the Heisman since Devonta Smith in 2020 as he sits at +1000 odds to secure the award. The stakes have certainly increased with the season beginning to wind down with the next few games set to make or break this race. 

Week 10 college football betting picks

With plenty on the line this week, here is a look at the best value on the betting slate and a breakdown of each matchup.

Georgia vs. 14 Missouri: Georgia -15 outcome at -110 odds (Unibet)

• Date and Time: Saturday, November 4th, 3:30 PM EST
• Location: Athens, Georgia
• TV/Stream: CBS

The Georgia Bulldogs are reigning back-to-back National Champions and have not lost a game since December 4^th, 2021. Despite holding an 8-0 record, it feels like the momentum and hype surrounding Georgia has slowed down. The Bulldogs are sure to be feeling this and looking to make a statement after dropping to second in the first playoff rankings. They have a perfect opportunity to prove themselves once again against a Missouri team that has a 7-1 record and have climbed to the highest they have been in the AP poll since 2014.

Ranking 14^th, Missouri has been playing some really good football and enter coming off a 34-12 victory against South Carolina. They are averaging an impressive 33.9 points per game which ranks 27^th among 133 qualifying Division 1 teams. Redshirt junior Brady Cook has taken a massive leap forward this season as he has cut down on his turnovers and has been hitting more explosive plays downfield.

Their offense has a balanced attack which includes 17 touchdowns through the air and 16 touchdowns on the ground this season. They also have only turned the ball over six times this year. The Tigers have also looked solid defensively allowing 1808 total yards on the season which ranks 60^th in the country. They also rank 54^th in scoring defense allowing 23.3 points per game.

However, Missouri has not been tested against a defense the caliber of Georgia. The Bulldogs are averaging 40.5 points per game on the year on offense while holding opponents to just 14.8 points per game which each rank 7^th in the country.

They most recently defeated Florida 43-20 in a game many had concerns about being an upset. Despite this, Georgia produced nearly 500 total yards of offense and the game was never in doubt. This is right on par with what they have produced this season as the offense has gained an average of 506.5 yards per game which ranks 4^th in college football. The Bulldogs also blew out Kentucky and Vanderbilt in the weeks prior. 

While Missouri should be proud of the strides they have taken as a program this season, expect Georgia to come out with a fire they are unable to match. This Georgia defensive line is set to cause some issues for Missouri and, despite the scepticism, the roster has been clicking on all cylinders. Look for them to centralize all doubts and make a statement about why they are the best team in college football.

Georgia has continually risen to the occasion in big moments over the past few years and this will be no different. They are still every bit the National Championship threats they were the past two seasons and will prove this by producing a blowout win against their highest-ranked opponent so far this year. You can wager on them to clear the 15-point spread at -110 odds on Unibet.

Bet on a Georgia -15 outcome at -110 with Unibet

Utah vs. Arizona State: Utah -11 at -110 odds (Betway)

• Date and time: Saturday, November 4th, 2:00 PM EST
• Location: Salt Lake City, Utah
• TV/Stream: Pac 12 Network

These two teams enter coming off opposite ends of the emotional spectrum. Utah suffered its toughest loss of the season as they were blown out 35-6 by Oregon to drop to 6-2 on the year. Despite QB Cam Rising officially being shut down for the season, there is still plenty of talent on the roster and the team has stepped up without him.

While the loss to Oregon was a punch in the mouth, they have a chance to bounce back in this matchup. On the other hand, Arizona State most recently defeated Washington State 38-27, snapping a six-game losing streak, to move to 2-6 on the year and 1-4 in conference play. This comes following consecutive losses at the hands of Washington, Colorado, California, USC, Fresno State, and Oklahoma State.

Utah has played a defensive-first style of play and they have not eclipsed 34 points in any game this season. They are holding opponents to just 17.5 points per game which ranks 18th in the country. However, they are producing just 21.2 points per game which is 109th out of the 133 qualifying Division 1 teams. While the loss to a solid Oregon squad is not something to hang their heads about, Utah played far from their best football last week.

QB Bryson Barnes completed just 15 of his 29 pass attempts for just 136 yards and a pair of interceptions in the loss. This also snapped an 18-game home winning streak for Utah. They will have a chance to start this streak again as Arizona State will travel to Utah for this matchup. Utah has won and covered their past two matchups and Utah is 4-1 ATS all time when at home against Arizona State. The Utes also defeated Arizona State by three touchdowns last year.

While quarterback injuries have been the root of most of their struggles, Arizona State has been a poor football team this season. They are allowing 26.5 points per game on the season while scoring just 19.6 which ranks 118th out of the 133 qualifying teams. There have been five different players who attempted a pass for the Sun Devils this season, although Trenton Bourguet has provided some stability in recent weeks.

Even with the quarterback play improving, there is just not enough talent on the roster to match up with this hungry Utah team. Expect the Utes to take advantage of this get-right spot and produce a convincing victory. While last week they were disappointing they have impressed all season and will return to form in this matchup. You can bet on them to cover the 11-point spread at -110 odds on Betway Sportsbook.

Bet on a Utah -11 outcome at -110 with Betway

Oklahoma vs. Oklahoma State: Oklahoma State +6 outcome at -110 odds (BetMGM)

• Date and time: Saturday, November 4th, 3:30 PM EST
• Location: Stillwater, Oklahoma
• TV/Stream: ABC

This showdown between 9^th-ranked Oklahoma and Oklahoma State will be the last Bedlam matchup for the foreseeable future. The cross-state rivals will put a halt on this matchup as Oklahoma makes the jump from the Big 12 to the Southeastern Conference next season. There has been a matchup between these teams every season since 1910 with Oklahoma leading the series 91-19-7. However, these teams are much more evenly matched than has traditionally been the case. With both teams having some reasons for optimism this year, count on Oklahoma State being a live dog as they look to make a final statement in this rivalry matchup. 

While they have been considered one of the top teams in college football for most of the season, Oklahoma should still be kept on fraud watch. The Sooners hold a record of 7-1, but they are coming off a 38-33 loss to Kansas last week and narrowly defeated UCF 31-29 the week before. Statistically, they have shined, ranking seventh in the country in total offense at 489.8 yards per game and 4^th in scoring at 42.2 points per game. They also are holding opponents to just 18.9 points per game which is the 23^rd best rate in the country. Dillon Gabriel has looked sharp this season passing for 2302 passing yards and tossing for 19 touchdowns and four interceptions. The biggest question will be if this defense can withstand Oklahoma State’s rushing attack which is concerning as they allowed 225 rushing yards against Kansas last week. 

Entering with a 6-2 record on the season, Oklahoma State has plenty of reasons to be optimistic in this matchup. On the season they have produced 31.1 points per game while allowing 24.4 points per game which each rank in the top 60. They are riding an impressive four-game winning streak in which they defeated Kansas State, Kansas, West Virginia, and Cincinnati with each victory coming by a touchdown or more. Running back Ollie Gordon is leading the nation with 1087 rushing yards on the season. In the last two weeks alone, he has run for 553 yards and six touchdowns. While they are more of a rushing-oriented team, there is still a balance in the passing game that they can capitalize on as well. 

Expect this to be a hard-fought matchup in which emotions are high. While the moneyline may very well be in play, it is a safer bet to take the six-point spread. This game feels destined to come down to a one-possession score and for Oklahoma State to have a real chance to come out with the win. There is no better way to get revenge on your rival than to get the last laugh before the conference shift and expect them to do everything possible to make this happen. You can take them to get the win on the moneyline at +180 if you are feeling ultra-confident or take the safer option by wagering on the +6 spread at -110 odds on BetMGM.

Bet on an Oklahoma +6 outcome at -110 odds with BetMGM

College football betting weekly highlights

• Utah’s QB Cam Rising is out for the season as he recovers from a torn ACL
• Iowa QB Cade McNamara is out for the season with a torn ACL
• Ohio State QB Kyle McCord questionable vs Rutgers with foot injury
• Wisconsin RB Braelon Allen questionable with ankle sprain vs Indiana
  • Injured in the first half vs Ohio State and returned to the sideline with a walking boot
• Home teams are 390-205 this year straight up (65.5%)
• Away teams are 205-390 this year straight up (34.5%)
• Home teams are 276-304-13 against the spread this season (47.6%)
• Away teams are 304-276-13 against the spread this season (52.4%)
• Favorites are 285-295-13 against the spread this season (49.1%)
• Underdogs are 295-285-13 against the spread this season (50.9%)
• Home favorites are 191-210-9 against the spread this season (47.6%)
• Away favorites are 94-85-4 against the spread this season (52.5%)
• Home underdogs are 85-94-4 against the spread this season (47.5%)
• Overs are 298-284 on the season (51.2%)

Best college football betting sites

• BetMGM (Available in: AZ, CO, FL, IL, IN, IA, KS, LA, MD, MA, MI, MS, NV, NJ, NY, OH, OR, PA, PR, TN, VA, WA, WV, and WY)
• DraftKings (Available in: AZ, CO, CT, IL, IN, IA, KY, LA, MD, MA, MI, NH, NJ, NY, OH, OR, PA, TN, VA, and WV)
• BetRivers (Available in: AZ, CO, CT, IL, IN, IA, LA, MD, MI, NJ, NY, OH, PA, VA, WV, and WY)
• Unibet (Available in: AZ, IN, IA, NJ, PA, and VA)
• Desert Diamond (Available in: AZ)
• Betway (Available in: IA)

Big football fan? Check out the best NFL betting sites for the season!

Commercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 21+. T&Cs apply. Gambling Problem? Call 1-800-Gambler

Responsible gambling 

Remember to gamble responsibly
A responsible gambler is someone who:

• Establishes time and monetary limits before playing
• Only gambles with money they can afford to lose
• Never chase their losses
• Doesn’t gamble if they’re upset, angry, or depressed
• National Council on Problem Gambling – https://www.ncpgambling.org/
• Gamble Aware – www.begambleaware.org

For help with a gambling problem, call the National Gambling Helpline on 1-800-522-4700 or go to ncpgambling.org/chat