2025 MLB Win Total Predictions and Best Bets: Diamondbacks and Red Sox bounce back

While the 2025 MLB season got underway in Tokyo last week, the official start to the season will take place on Thursday, March 27 for the majority of the league. Opening Day is on the horizon and the marathon of the 162 game regular season is near. Here at Pickswise, we are building up to the new season and you can check out our MLB Division winners best bets and MLB Player Award best bets before the season starts.

For now, I’ll be breaking down my favorite MLB win totals that still have plenty of value as the season approaches. Featuring best bets from 3 different divisions, here are the MLB odds and my MLB picks for my favorite win totals on the board. Let’s get into it.  

Arizona Diamondbacks Over 86.5 wins (-115)

Odds available at DraftKings Sportsbook at time of publishing

Even though this number has ticked up a bit over the course of the offseason, the Diamondbacks to win at least 87 games is still one of my favorite preseason futures on the board. Unlike many teams this offseason, Arizona is a team that actively made a concerted effort to improve its roster and make a push to challenge the juggernauts at the top of the National League. And while I don’t think they’ll be quite on the level of the Dodgers or whoever comes out on top in the NL East, there’s no reason the Diamondbacks can’t win at least 90 games and make it back to the postseason.

For starters, Arizona’s deep rotation — now bolstered by the addition of Corbin Burnes — should be a force to be reckoned with, provided it stays healthy. Burnes joins Zac Gallen, Merrill Kelly, Eduardo Rodriguez and Brandon Pfaadt to make up one of the better units in the National League, which is a necessity when going up against the likes of the Dodgers and Padres all season long. At the dish, the Diamondbacks boast a rock-solid lineup that can hit for power and average, and should be one of the best base-stealing units in the sport. As long as the bullpen can come close to regaining its 2023 form, Arizona should be in great shape to be a legitimate contender in a loaded National League.

Lock in our MLB World Series predictions at +300 and +2500 odds

Miami Marlins Under 63.5 wins (-110)

Odds available at FanDuel Sportsbook at time of publishing

Did you know that the Houston Astros are paying more in dead money this upcoming season ($36.5 million) than the Marlins entire payroll? That alone sums up what we’re dealing with in Miami this season. While the Chicago White Sox are currently priced as the worst team in baseball by far (currently listed at 53.5 wins in the market), I firmly believe that this Marlins team has a chance to give them a run for their money in the race to the bottom this season. This is an organization that is completely hapless at the moment and appears to be without a coherent direction. Nearly every worthwhile player on the roster is gone, including Jesus Luzardo, Jake Burger moving to greener pastures this offseason. And while Miami is getting Sandy Alcantara and Eury Perez back in the rotation, there’s no guarantee that the front office won’t trade either (or both) of those pitchers in July, especially with a season outlook this bleak. This is a very young roster that is 2 years away from being 2 years away; it’s time to short the Marlins.

Boston Red Sox Over 86.5 wins (-115)

Odds available at DraftKings Sportsbook at time of publishing

In my Division Winner predictions piece, I tabbed the Red Sox as one of the best bets still remaining on the board, so it’s only natural that I’ll also be backing Boston to clear its win total this season. After multiple offseasons of sitting on their hands, the Red Sox finally went out and made improvements to a roster that already had clear potential. The additions of Garrett Crochet and Walker Buehler should sure up a rotation that already has a promising #2 starter in Tanner Houck, plus a few decent depth arms. At the plate, Boston will be formidable once again, thanks to the likes of Rafael Devers, Jarren Duran and Triston Casas. However, it’s the addition of Alex Bregman to replace Tyler O’Neil that has me more bullish on the Red Sox lineup than in previous seasons. If Boston is simply able to churn out a bullpen that hangs around the middle of the pack this season, there’s real potential for the Red Sox to win 90 games in a noticeably weaker, and already banged up AL East.

The post 2025 MLB Win Total Predictions and Best Bets: Diamondbacks and Red Sox bounce back appeared first on Pickswise.