NFL Week 2 Opening Odds, Betting Lines, and spreads: Target the Colts in Green Bay

Week 1 of the 2024 NFL regular season is nearly in the books, and what a week it’s been. We had massive upsets, close games galore and exciting plays around the league. How will Week 2 deliver an encore? Well, it should begin with a bang, as Thursday Night Football features the Buffalo Bills heading to Miami to take on the Dolphins in a pivotal AFC East showdown.

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 2 opening lines and give our best early bet to make.  

NFL Week 2 opening lines and odds 

Odds courtesy of DraftKings Sportsbook and available at time of publishing.  

• Buffalo Bills +1.5 (-115) vs Miami Dolphins -1.5 (-105) – Thursday Night Football  
• Indianapolis Colts -3 (-110) vs Green Bay Packers +3 (-110) 
• Las Vegas Raiders +8 (-110) vs Baltimore Ravens -8 (-110)  
• New Orleans Saints +6.5 (-110) vs Dallas Cowboys -6.5 (-110)  
• Seattle Seahawks -3 (-110) vs New England Patriots +3 (-110)   
• San Francisco 49ers -5.5 (-115) vs Minnesota Vikings +5.5 (-105) 
• Los Angeles Chargers -5.5 (-110) vs Carolina Panthers +5.5 (-110)  
• New York Jets -4 (-110) vs Tennessee Titans +4 (-110)
• New York Giants +2.5 (-110) vs Washington Commanders -2.5 (-110)  
• Cleveland Browns +3 (-105) vs Jacksonville Jaguars -3 (-115)  
• Tampa Bay Buccaneers +6.5 (-110) vs Detroit Lions -6.5 (-110) 
• Las Angeles Rams -1.5 (-110) vs Arizona Cardinals +1.5 (-110)
• Cincinnati Bengals +6 (-110) vs Kansas City Chiefs -6 (-110)
• Pittsburgh Steelers -3 (-110) vs Denver Broncos +3 (-110) 
• Chicago Bears +6.5 (-110) vs Houston Texans -6.5 (-110) — Sunday Night Football  
• Atlanta Falcons +6 (-110) vs Philadelphia Eagles -6 (-110) — Monday Night Football

Best early bet for NFL Week 2: Indianapolis Colts -3 over Green Bay Packers (-110) 

Anthony Richardson missed the majority of last season due to injury, but the Colts young quarterback has always had immense talent. That talent showed itself in Week 1, as Indianapolis was going blow for blow with one of the best teams in football, in large part thanks to Richardson’s tremendous dual threat ability and Shane Steichen’s brilliance as an offensive mind. While the Colts ultimately came up short last Sunday, I fully believe they’ll bounce back against a Packers defense that had all sorts of issues in a Week 1 loss against the Eagles, allowing 410 yards of offense and 34 points, despite getting 3 turnovers from Philadelphia in that game. The big news, however, is that Jordan Love is expected to miss 3-6 weeks with an MCL sprain suffered in the final minute of that contest in Brazil. This puts Packers head coach Matt LaFleur in the unenviable position of likely having to start Malik Willis, who is simply not an NFL quarterback at this stage of his career. Even on the road, I love the spot and matchup advantages the Colts have in this game. Let’s lay the field goal before it steams across this key number.

We’ll have NFL Week 2 picks for every game! 

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