College football Week 2 opening lines: Georgia expected to build on big win

The college football season trudging right along into its second full week of action. There is no Georgia vs Clemson kind of matchup on the schedule, but there are two more all-top 25 contests on offer (Oregon vs Ohio State and Iowa vs Iowa State).

College football Week 2 lines

The opening week of games were spread across a handful of days, but a more traditional second week of the 2021 college football season takes place on Friday and Saturday. Let’s look at the early lines, courtesy of DraftKings Sportsbook.

Friday
Kansas +25 at Coastal Carolina
UTEP +26 at Boise State

Saturday
Illinois +10 at Virginia
Oregon +14.5 at Ohio State
Pittsburgh -3.5 at Tennessee
South Carolina +1 at East Carolina
Miami (OH) +20 at Minnesota
Tulsa +13 at Oklahoma State
Florida -28 at South Florida
Middle Tennessee +20.5 Virginia Tech
Toledo +16.5 at Notre Dame
Purdue -33.5 at UConn
Ball State +23 at Penn State
Boston College -37 at Massachusetts
Air Force -5.5 at Navy
UAB +24.5 at Georgia
California +11.5 at TCU
Buffalo +13.5 at Nebraska
Texas A&M -17 at Colorado
Iowa +4.5 at Iowa State
Texas -6.5 at Arkansas
Eastern Michigan +26 at Wisconsin
Appalachian State +9 at Miami (FL)
NC State -2.5 at Mississippi State
Missouri +5 at Kentucky
Georgia State +25.5 at North Carolina
Washington +6.5 at Michigan
Vanderbilt +7 at Colorado State
San Diego State -1.5 at Arizona
Stanford +17 at USC
UNLV +33.5 at Arizona State
Hawaii +11 at Oregon State

Make sure you check out our previews for all of these games later in the week

Week 2 games to watch

Oregon vs Ohio State is the must-watch game of the week—one that has serious College Football Playoff implications. The defending Pac-12 champion Ducks are heading to Columbus with a No. 12 ranking in tow, while the Buckeyes enter at No. 3 (they were leapfrogged by Georgia following the Bulldogs’ win over Clemson). Ohio State is giving more than two touchdowns to the visitors.

Read our early Oregon vs Ohio State preview

As for Iowa vs Iowa State, that is expected to be an extremely competitive contest. Despite playing on the road, the Hawkeyes are getting only 4.5 points. They are coming off a 34-6 humiliation of then-No. 17 Indiana, so this is a team already full of confidence. The Cyclones were hardly impressive during a 16-10 victory over Northern Iowa.

Elsewhere on the schedule, Georgia will try to build on its defeat of Clemson when it faces what should be a much softer matchup with UAB. UGA is a -24.5 home favorite over the Blazers. Obviously the Bulldogs’ offense, which produced only 3 points against the Tigers, must improve in order to cover such a lofty spread (Georgia’s only touchdown last week came via a pick-6).

At Pickswise we offer free expert College Football Picks and College Football Predictions for all games in the Power Five conferences and the top 25 teams outside of Power five, including our College Football Parlay picks each week.

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